I'm happy with how I've played at the 200s/220s so far. I'm actually doing fine in them (8%ish ROI in 220s so far). It usually takes me a few attempts at moving up to a new level before I'm ready to deal with the swings for good.
220s Graph:

I'm going to be moving down to the 110's and put in high volume for the next couple weeks until I'm ready to move up again. It's the best decision for me financially, since my $/hr is higher 3 tabling 110s, as opposed to 2 tabling 220s.
October has been a pretty terrible month in terms of profits for my standards. I'm about +4k now after a nice downswing in 220 4 mans with Primo yesterday. I'm hoping to put a couple solid, high volume days together to round out the month at the 110s. I'd really like to finish the month at 5k+.
In the end, the most important stat in this game is Total Profit.
Good Luck.